Optical resolution of racemic 2-hydroxy octanoic acid by lipase-catalyzed hydrolysis in a biphasic membrane reactor |
| |
Authors: | Keiji Sakaki Naotsugu Itoh |
| |
Institution: | (1) National Institute of Advanced Industrial Science and Technology (AIST) Tsukuba, Ibaraki, 305-8565, Japan |
| |
Abstract: | Racemic 2-hydroxy octanoic acid methyl ester was optically resolved by lipase-catalyzed hydrolysis in a biphasic membrane reactor using hydrophilic/hydrophobic capillary membranes. In a buffer/hexane biphasic membrane reactor using hydrophilic ultrafiltration membranes, (S)-2-hydroxy octanoic acid was recovered from the aqueous phase at 59–67% yield and 0.9–0.92 enantiomeric excess (ee), and the ester of (R)-isomer was recovered from the organic phase at 73–75% yield and 0.92–0.99 ee. |
| |
Keywords: | enzyme membrane reactor 2-hydroxy octanoic acid lipase optical resolution |
本文献已被 PubMed SpringerLink 等数据库收录! |