An in vitro approach to the study of target organ toxicity of drugs and chemicals |
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Authors: | Daniel Acosta Elsie M B Sorensen David C Anuforo David B Mitchell Kenneth Ramos Kenneth S Santone Mary Ann Smith |
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Institution: | (1) Department of Pharmacology and Toxicology, College of Pharmacy, The University of Texas, 78712 Austin, Texas |
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Abstract: | Summary A major goal of our laboratory has been the development of primary culture systems that retain differentiated fucntions and
responses characteristic of intact tissues in vivo. Specifically, we have developed cellular models of primary cultures of
rat heart, liver, and kidney cells to explore the mechanisms by which drugs or chemicals may be toxic to key organs of the
body and to develop new techniques by which xenobiotics may be evaluated or identified as potential toxicants to living systems.
The purpose of this paper is to describe our rationale and approach to the study of target organ toxicology with in vitro
cellular systems. |
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Keywords: | in vitro target organ toxicity |
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