Promoting the formation of tetramolecular G-quadruplexes under freezing condition |
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| Authors: | Zhai Qianqian Deng Minggang Xu Liang Zhang Xiaolian Zhou Xiang |
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| Institution: | College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, State Key Laboratory of Virology, Wuhan University, Hubei, Wuhan 430072, PR China. |
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| Abstract: | In the study, we demonstrated that freezing was able to facilitate the short DNA strand T(4)G(4) to self-assemble into a tetramolecular G-quadruplex with a low DNA concentration in the absence of any ligand, providing a fast approach to configure intermolecular G-quadruplexes. The fast formation of intermolecular G-quadruplexes may offer a convenient tool. |
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