Pharmacokinetic data of propranolol enantiomers in a comparative human study with (S)- and (R,S)-propranolol |
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Authors: | W Lindner M Rath K Stoschitzky H J Semmelrock |
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Affiliation: | Institute of Pharmaceutical Chemistry, Karl-Franzens-University of Graz, Austria. |
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Abstract: | The pharmacokinetics of (S)-propranolol were compared after the oral administration of a 40 mg dose of the pure enantiomer and an 80 mg dose of a racemic mixture of (R,S)-propranolol. The results of this study indicate that the bioavailability of (S)-propranolol, as expressed by the mean area under the concentration-time curve (AUC) and maximum serum concentration, is lower after 40 mg of the optically pure drug than after the racemic drug. |
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Keywords: | (S)-, (R,S)-propranolol pharmacokinetic human study |
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