Synthesis, biodistribution and micro-PET imaging of radiolabeled antimitotic agent T138067 analogues |
| |
Authors: | Fei Xiangshu Zheng Qi-Huang Wang Ji-Quan Stone K Lee Martinez Tanya D Miller Kathy D Sledge George W Hutchins Gary D |
| |
Institution: | Department of Radiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. |
| |
Abstract: | Radiolabeled antimitotic agents 11C]T138067 and 18F]T138067 have been synthesized for evaluation as new potential positron emission tomography (PET) biomarkers for cancer imaging. In vivo biodistribution and micro-PET imaging of 11C]T138067 were performed in breast cancer animal models MCF-7 transfected with IL-1alpha implanted athymic mice and MDA-MB-435 implanted athymic mice. The results suggest that the uptakes of 11C]T138067 in both MCF-7 transfected with IL-1alpha tumor and MDA-MB-435 tumor are non-specific binding. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|