Crossreactive antigens between life cycle stages of plasmodium falciparum

The high mortality and morbidity induced by falciparum malaria has motivated research to find an efficient antimalarial vaccine. The parasite has a complex life cycle, both in the mosquito and human hosts, and presents a number of potential targets for vaccine-induced immune attack. Here, Inge Moelans and John Schoenmakers discuss how the search for protective antigens has been complicated by the discovery of multiple crossreactivities between different parasite proteins.