Electron microscopic study on the interaction of Sendai virus with liposomes containing glycophorin |
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| Authors: | Naoto Oku Keizo Inoue Shoshichi Nojima Takashi Sekiya Yoshinori Nozawa |
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| Institution: | 1. Department of Health Chemistry, Faculty of Pharmaceutical Sciences, The University of Tokyo, Hongo, Tokyo Japan;2. Department of Biochemistry, Gifu University, School of Medicine, Gifu Japan |
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| Abstract: | The interaction of liposomes containing glycophorin, a major sialoglycoprotein of human crythrocytes, with Sendai virus was studied by freeze-fracture and negative staining electron-microscopy. Viral envelopes were absorbed on liposomal membranes at 0°C. When the temperature was shifted up to 37°C, the viral envelopes fused with the liposomal membranes (envelope fusion). Particles representing viral membrane components formed clusters on liposomal membranes after incubation for more than 1 h at 37°C. |
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| Keywords: | Liposome Glycophorin Viral envelope Freeze-fracture Electron microscopy (Sendai virus) |
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