Auto-oxidation-induced fusion of lipid vesicles |
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| Authors: | Klaus Gast Dietrich Zirwer Axel-Michael Ladhoff Joachim Schreiber Regine Koelsch Konrad Kretschmer Jürgen Lasch |
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| Affiliation: | 1. Central Institute of Molecular Biology of the Academy of Sciences of the G.D.R., 1115 Berlin, Lindenberger Weg 70 G.D.R.;2. Department of Electron Microscopy of the Pathological Institute of the Humboldt University, Berlin G.D.R.;3. Central Institute of Isotope and Radiation Research, 1115 Berlin, Lindenberger Weg 70 G.D.R.;4. Institute of Physiological Chemistry of the Martin Luther University, Halle (Saale G.D.R. |
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| Abstract: | Spontaneous size changes of small unilamellar vesicles with initial mean diameters of 25 nm measured by quasi-elastic light scattering (QELS) and electron microscopy are reported. After the size conversion the vesicles have mean diameters of about 70 nm and are of the unilamellar and multilamellar type. The fact that auto-oxidation initiates this process is established by the comparison of the results for vesicles which differ only in the degree of auto-oxidation. The role of phosphatidylcholine hydroperoxides as fusogens is discussed. |
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| Keywords: | Lipid auto-oxidation Membrane stability Liposome fusion QELS quasi-elastic light scattering |
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