The interaction of phospholipid membranes with poly(ethylene glycol). Vesicle aggregation and lipid exchange |
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| Authors: | Colin P.S. Tilcock Derek Fisher |
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| Affiliation: | 1. Department of Biochemistry, The University of British Columbia, Vancouver, B.C. V6T 1W5 Canada;2. Department of Biochemistry and Chemistry, Royal Free Hospital School of Medicine, The University of London, 8 Hunter Street, London WC1N 1BP U.K. |
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| Abstract: | (1) The water soluble polymer, poly(ethylene glycol), causes aggregation of sonicated vesicles of dimyristoylphosphatidylcholine in a manner consistent with a steric exclusion mechanism. (2) Poly(ethylene glycol) promotes the exchange of lipids between multilamellar vesicles of dimyristoylphosphatidylcholine and dipalmitoylphosphatidylcholine when the lipids are in the liquid-crystalline state. (3) 31P-NMR studies demonstrate that the bilayer configuration of smectic mesophases of dipalmitoylphosphatidylcholine is substantially maintained in the presence of poly(ethylene glycol). |
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| Keywords: | Poly(ethylene glycol) Vesicle aggregation Lipid exchange PEG poly(ethylene glycol) DSC differential scanning calorimetry EDTA ethylenediaminetetraacetic acid |
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