Successive phase-transition phenomena and phase diagram of the phosphatidylcholine-water system as revealed by differential scanning calorimetry |
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Authors: | Michiko Kodama Mika Kuwabara Syûzô Seki |
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Institution: | Department of Chemistry, Faculty of Science, Kwansei Gakuin University, Nishinomiya, 662 Japan |
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Abstract: | A completely dehydrated dipalmitoylphosphatidylcholine (DPPC) was prepared with dehydration under high vacuum and at a temperature above its main transition temperature. Thermal analyses on about forty different samples of the DPPC-water system indicated that the main transition temperature decreased stepwise with an increase in the water content to the limiting temperature at 42.6°C, reflecting the thermal behaviors of a total of five endothermic peaks. The pretransition appeared at a water content above 17 g%, and the predominant role of ‘newly incorporated water’ between the bilayers of DPPC molecules at the pretransition was made evident. |
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Keywords: | Phosphatidylcholine-water system Bilayer Dipalmitoylphosphatidylcholine Phase transition Interlamellar water Differential scanning calorimetry |
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