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The rate of fusion of phospholipid vesicles and the role of bilayer curvature |
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| Authors: | Shlomo Nir Jan Wilschut Joe Bentz |
| Affiliation: | 1. Seagram Centre for Soil and Water Sciences, Faculty of Agriculture, Hebrew University of Jerusalem, Rehovot 76100 Israel;2. Laboratory of Physiological Chemistry, University of Groningen, Bloemsingel 10, 9712 KZ Groningen The Netherlands;3. Department of Experimental Pathology, Roswell Park Memorial Institute, Buffalo, NY 14263 U.S.A. |
| Abstract: | Kinetics of Ca2+-induced fusion of phosphatidylserine vesicles is studiied for lipid concentrations varying from 1 μM to 100 μM. Fusion is monitored by mixing of aqueous vesicle contents and by explicitly accounting for leakage. The analysis provides separately rates of aggregation and fusion. The rate of fusion per se decreases steeply with vesicle size. |
| Keywords: | Fusion rate Phospholipid Bilayer curvature |
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