Correcting effect of the locus coeruleus on ophthalmic hypertension of the hypothalamic genesis

We studied the intraocular pressure and the humor aquosus volume changes after a chronic emotional stress produced by a prolonged electrical stimulation of the multiple ventromedial (VMHN) hypothalamic nuclei and the locus coeruleus. The VMHN stimulation caused an increase in the intraocular pressure and production of the humor aquosus, as well as a decrease in the outflow ratio. Stimulation of the locus coeruleus increased the intraocular pressure to a lesser extent. A combined effect of both types of stimulation normalised the intraocular pressure due to a decrease in the humor aquosus production, the outflow ratio remaining unchanged.