The characterization of phospholipids associated with microtubules, purified tubulin and microtubule associated proteins in vitro |
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Authors: | A J Hargreaves W G McLean |
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Institution: | School of Pharmacy, Liverpool Polytechnic, England. |
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Abstract: | 1. Significant levels of total phospholipid phosphate were detected in highly purified microtubule protein preparations. 2. While the phospholipid profiles of total microtubule proteins and microtubule-associated proteins showed both similarities and differences to that of a whole brain homogenate, purified tubulin was associated only with phospholipids that were not detectable in the latter. 3. Phosphatidyl ethanolamine, found exclusively in a fraction of microtubule associated proteins, stimulated microtubule assembly in vitro. |
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