| 白细胞介素－2的中枢镇痛作用 |
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| 引用本文： | 蒋春雷,徐荻,郑仲承,范佩芳,刘新垣, 由振东,宋朝佑,王成海,路长林. 白细胞介素－2的中枢镇痛作用[J]. 中国应用生理学杂志, 1994, 0(4) |
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| 作者姓名： | 蒋春雷 徐荻 郑仲承 范佩芳 刘新垣 由振东 宋朝佑 王成海 路长林 |
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| 作者单位： | 中国科学院生物化学研究所 第二军医大学神经生物学教研室(蒋春雷，徐荻，郑仲承，范佩芳，刘新垣)，( 由振东，宋朝佑，王成海，路长林) |
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| 摘 要： | 本实验采用侧脑室给药，以钾离子透入法引起大鼠甩尾反应为指标，测定动物的痛阈，发现白细胞介素－２（ＩＬ－２）具有显著提高大鼠痛阈的作用，此作用能被抗ＩＬ－２单克隆抗体所阻断。纳洛酮能反转ＩＬ－２的镇痛作用，表明其作用机理与阿片受体有关。
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| 关 键 词： | 白细胞介素－2，痛阈，阿片受体，侧脑室，中枢神经系统 |
THE CENTRAL ANALGESIC EFFECT OF IL-2 |
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| Jiang Chunlei,Xu Di,Zheng Zhongcheng,Fan Peifang,Liu Xinyuan. THE CENTRAL ANALGESIC EFFECT OF IL-2[J]. Chinese journal of applied physiology, 1994, 0(4) |
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| Authors: | Jiang Chunlei Xu Di Zheng Zhongcheng Fan Peifang Liu Xinyuan |
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| Affiliation: | Jiang Chunlei*,Xu Di,Zheng Zhongcheng,Fan Peifang,Liu Xinyuan |
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| Abstract: | Using the potassium iontophoresis to induce tail-flick as pain marker,it was found that the pain threshold was increased significantly after injecting IL-2into the lateral ventricle of rats andthis effect was abolished by McAb to IL-2.Naloxone could inhibit the analgesic effect of IL-2,suggesting that the analgesic effect of IL-2 is related to the opiate receptors. |
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| Keywords: | interleukin-2 pain threshold opiate receptors lateral ventricle central nervous system*Department of Neurobiology The Second Military Medical University |
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