Nuclear staining and relative distance for quantifying epidermal differentiation in biomarker expression profiling |
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| Authors: | Thora Pommerencke Thorsten Steinberg Hartmut Dickhaus Pascal Tomakidi Niels Grabe |
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| Institution: | (1) Hamamatsu Tissue Imaging and Analysis (TIGA) Center, BIOQUANT, University Heidelberg, BQ0010, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany;(2) Institute for Medical Biometry and Informatics, University Hospital Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany;(3) Department of Orthodontics and Dentofacial Orthopedics, Dental School University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany |
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| Abstract: | Background The epidermal physiology results from a complex regulated homeostasis of keratinocyte proliferation, differentiation and death
and is tightly regulated by a specific protein expression during cellular maturation. Cellular in silico models are considered a promising and inevitable tool for the understanding of this complex system. Hence, we need to incorporate
the information of the differentiation dependent protein expression in cell based systems biological models of tissue homeostasis.
Such methods require measuring tissue differentiation quantitatively while correlating it with biomarker expression intensities. |
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