IR spectroscopic research on the impact of chemical analogues of autoregulatory d1 factors of microorganisms on structural changes in DNA |
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Authors: | O. K. Davydova D. G. Deryabin G. I. El’-Registan |
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Affiliation: | (1) Orenburg State University, Russia;(2) Winogradsky Institute of Microbiology, Russian Academy of Sciences, pr. 60-letiya Oktyabrya 7, k. 2, Moscow, 117312, Russia |
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Abstract: | Using IR spectroscopy, we investigated the impact of chemical analogues of autoregulatory d1 factors of microorganisms (methylresorcinol, hexylresorcinol, and tyrosol) on the conformational changes in DNA in films upon altering (decreasing) the relative humidity. We analyzed the appearance/disappearance of characteristic absorption bands of A and B DNA forms and determined D 1088/D 1224, the ratio between the band intensities of symmetrical and asymmetrical oscillations in their phosphate groups. The data obtained suggest the slowing down of the B → A structural transition in DNA in the presence of methylresorcinol and its speeding up in the presence of tyrosol. We discuss the mechanisms of this phenomenon in relation to the chemical composition of d 1 factors and their biological function. |
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Keywords: | DNA conformational state microbial autoregulatory d1 factors alkylresorcinols IR spectroscopy |
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