Increased intracellular Ca2+ is necessary for maximal expression of the proto-oncogene c-jun in the Jurkat T-cell line. |
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| Authors: | M L Vandenplas W L Mouton S Vandenplas A J Bester M H Ricketts |
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| Affiliation: | Department of Medical Physiology and Biochemistry, University of Stellenbosch, Faculty of Medicine, Tygerberg, Republic of South Africa. |
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| Abstract: | The time course and signal-transduction requirements for proto-oncogene c-jun expression in T-cells were investigated. Expression of c-jun mRNA was evident at 30 min after stimulation. Both the activation of Ca2+/phospholipid-dependent kinase as well as an increased intracellular free Ca2+ concentration were necessary for the maximal induction of c-jun mRNA and synthesis of Jun protein 1 h after stimulation. |
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