| 去乙酰化转移酶SIRT7的作用及机制研究进展 |
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| 引用本文： | 李林,董振,杨洁,李倩,雷倩,毛景欣,杨丽群,崔红娟. 去乙酰化转移酶SIRT7的作用及机制研究进展[J]. 生物工程学报, 2019, 35(1): 13-26 |
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| 作者姓名： | 李林 董振 杨洁 李倩 雷倩 毛景欣 杨丽群 崔红娟 |
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| 作者单位： | 西南大学家蚕基因组生物学国家重点实验室;西南大学重庆市蚕丝生物材料与再生医学工程技术研究中心;西南大学肿瘤生物医学与转化工程研究中心;河北医科大学第三附属医院皮肤科 |
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| 基金项目： | 国家自然科学基金 (No. 31672496)，重庆高校创新团队建设计划 (No. CXTDX201601010)，重庆市基础与前沿研究计划项目 (No. cstc2016jcyjA0425) 资助。 |
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| 摘 要： | SIRT7是哺乳动物Sirtuins家族中的一员,定位于核仁,是一种高度特异性的H3K18Ac(组蛋白H3的乙酰化18位赖氨酸残基)去乙酰化酶。近年来的研究发现SIRT7可通过多种途径参与调控核糖体RNA转录、细胞代谢、细胞应激以及DNA损伤修复等生理过程。此外,SIRT7还与衰老、心脏疾病及脂肪肝等密切相关。特别是SIRT7在多种肿瘤如肝癌、胃癌、乳腺癌、膀胱癌、结直肠癌、胰腺癌和头颈鳞状细胞癌等发生发展中起着重要的调节作用。文中综述了SIRT7的细胞及分子生物学作用,并系统总结了其在人类疾病中的研究现状。
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| 关 键 词： | SIRT7，去乙酰化，肿瘤，细胞代谢，核糖体，应激反应 |
| 收稿时间： | 2018-04-12 |
Progress in roles and mechanisms of deacetylase SIRT7 |
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| Lin Li,Zhen Dong,Jie Yang,Qian Li,Qian Lei,Jingxin Mao,Liqun Yang and Hongjuan Cui. Progress in roles and mechanisms of deacetylase SIRT7[J]. Chinese journal of biotechnology, 2019, 35(1): 13-26 |
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| Authors: | Lin Li Zhen Dong Jie Yang Qian Li Qian Lei Jingxin Mao Liqun Yang Hongjuan Cui |
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| Affiliation: | 1 State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China; 2 Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Southwest University, Chongqing 400716, China; 3 Engineering Research Center for Cancer Biomedical and Translational Medicine, Southwest University, Chongqing 400716, China,1 State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China; 2 Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Southwest University, Chongqing 400716, China; 3 Engineering Research Center for Cancer Biomedical and Translational Medicine, Southwest University, Chongqing 400716, China,1 State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China; 2 Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Southwest University, Chongqing 400716, China; 3 Engineering Research Center for Cancer Biomedical and Translational Medicine, Southwest University, Chongqing 400716, China,4 Department of Dermatology, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, Hebei, China,1 State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China; 2 Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Southwest University, Chongqing 400716, China; 3 Engineering Research Center for Cancer Biomedical and Translational Medicine, Southwest University, Chongqing 400716, China,1 State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China; 2 Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Southwest University, Chongqing 400716, China; 3 Engineering Research Center for Cancer Biomedical and Translational Medicine, Southwest University, Chongqing 400716, China,1 State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China; 2 Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Southwest University, Chongqing 400716, China; 3 Engineering Research Center for Cancer Biomedical and Translational Medicine, Southwest University, Chongqing 400716, China and 1 State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China; 2 Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Southwest University, Chongqing 400716, China; 3 Engineering Research Center for Cancer Biomedical and Translational Medicine, Southwest University, Chongqing 400716, China |
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| Abstract: | |
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| Keywords: | SIRT7 deacetylation tumor cell metabolism ribosome stress response |
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