Evolutionary divergence in the fungal response to fluconazole revealed by soft clustering |
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| Authors: | Dwight Kuo Kai Tan Guy Zinman Timothy Ravasi Ziv Bar-Joseph Trey Ideker |
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| Institution: | (1) Departments of Bioengineering and Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA;(2) Departments of Internal Medicine and Biomedical Engineering, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA;(3) Department of Computer Science, Carnegie Mellon University, 500 Forbes Avenue, Pittsburgh, PA 15213, USA;(4) Red Sea Laboratory of Integrative Systems Biology, Division of Chemical and Life Sciences and Engineering, Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Kingdom of Saudi Arabia |
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| Abstract: | Background Fungal infections are an emerging health risk, especially those involving yeast that are resistant to antifungal agents. To
understand the range of mechanisms by which yeasts can respond to anti-fungals, we compared gene expression patterns across
three evolutionarily distant species - Saccharomyces cerevisiae, Candida glabrata and Kluyveromyces lactis - over time following fluconazole exposure. |
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