Synthesis and evaluation of 4-triazolylflavans as new aromatase inhibitors |
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| Authors: | Yahiaoui Samir Pouget Christelle Fagnere Catherine Champavier Yves Habrioux Gérard Chulia Albert José |
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| Institution: | UPRES EA 1085 Biomolécules et Cibles Cellulaires Tumorales, Faculté de Pharmacie, 2 rue du Docteur Marcland, 87025 Limoges, France. |
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| Abstract: | Aromatase is a target of pharmacological interest for the treatment of estrogen-dependent cancers. Azole derivatives such as letrozole or anastrozole have been developed for aromatase inhibition and are used for the treatment of breast tumors. In this paper, four 4-triazolylflavans were synthesized and were found to exhibit moderate to high inhibitory activity against aromatase. |
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