Indolomonoterpenic alkaloids from Strychnos icaja roots |
| |
Authors: | Philippe Geneviève De Mol Patrick Zèches-Hanrot Monique Nuzillard Jean-Marc Tits Monique-Hanrot Angenot Luc Frédérich Michel |
| |
Institution: | University of Liège, Natural and Synthetic Drugs Research Center, Laboratoire de Pharmacognosie, Avenue de l'H?pital 1, B36, B-4000 Liège, Belgium. |
| |
Abstract: | In the course of our search for new antiplasmodial alkaloids from Strychnos icaja, we have isolated five alkaloids: three monomers, protostrychnine and genostrychnine, previously described in Strychnos nux-vomica, pseudostrychnine, already found in the leaves of the plant, a new bisindolic alkaloid, named strychnogucine C, and the first naturally occurring trimeric indolomonoterpenic alkaloid: strychnohexamine. This latter trimeric alkaloid presented an antiplasmodial activity against the FCA Plasmodium falciparum line near 1 microM. |
| |
Keywords: | Loganiaceae Strychnos icaja Indolomonoterpenic alkaloid Strychnogucine C Protostrychnine Strychnohexamine Plasmodium falciparum |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|