Electroacupuncture alters the expression of genes associated with lipid metabolism and immune reaction in liver of hypercholesterolemia mice |
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Authors: | Yaoxia Kang Min Li Wenqi Yan Xingjie Li Jinmei Kang Yizheng Zhang |
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Institution: | (1) College of Life Science, Sichuan University, Chengdu, Sichuan, 610064, P.R. China;(2) Center for Disease Control of Baotou in Inner Mongolia, Baotou, P.R. China |
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Abstract: | Acupuncture or electroacupuncture (EA) is effective in treating various metabolism disorders. Previously we found that EA
at the acupoint, Fenglong (ST40), had the cholesterol-lowering effect and regulated genes expression in liver of hypercholesterolemia
mice (M Li and YZ Zhang, Int J Mol Med 2007, 19: 617–629). To explain gene expression associated with EA, suppression subtractive
hybridization (SSH), combined with targeted display (TD), was used and 26 up-regulated and 24 down-regulated genes with known
functions were identified in hypercholesterolemia mice liver, some of which are involved in key reactions of lipid metabolism
and immune reaction. Promoting lipid metabolism and suppressing inflammation via modulating mRNA expression may be the mechanism
of EA inducing modulation of cholesterol concentrations. |
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Keywords: | Electroacupuncture Gene expression Hypercholesterolemia Mice Suppression subtractive hybridization |
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