Genome of the opportunistic pathogen Streptococcus sanguinis |
| |
Authors: | Xu Ping Alves Joao M Kitten Todd Brown Arunsri Chen Zhenming Ozaki Luiz S Manque Patricio Ge Xiuchun Serrano Myrna G Puiu Daniela Hendricks Stephanie Wang Yingping Chaplin Michael D Akan Doruk Paik Sehmi Peterson Darrell L Macrina Francis L Buck Gregory A |
| |
Affiliation: | Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA 23284-2030, USA. |
| |
Abstract: | The genome of Streptococcus sanguinis is a circular DNA molecule consisting of 2,388,435 bp and is 177 to 590 kb larger than the other 21 streptococcal genomes that have been sequenced. The G+C content of the S. sanguinis genome is 43.4%, which is considerably higher than the G+C contents of other streptococci. The genome encodes 2,274 predicted proteins, 61 tRNAs, and four rRNA operons. A 70-kb region encoding pathways for vitamin B(12) biosynthesis and degradation of ethanolamine and propanediol was apparently acquired by horizontal gene transfer. The gene complement suggests new hypotheses for the pathogenesis and virulence of S. sanguinis and differs from the gene complements of other pathogenic and nonpathogenic streptococci. In particular, S. sanguinis possesses a remarkable abundance of putative surface proteins, which may permit it to be a primary colonizer of the oral cavity and agent of streptococcal endocarditis and infection in neutropenic patients. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|