Optimization of recombinantEscherichia coli fed-batch fermentation for bovine somatotropin |
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| Authors: | Sung Kwan Yoon Seon Hun Kwon Myoung Gyu Park Whan Koo Kang Tai Hyun Park |
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| Institution: | (1) Lucky Biotech Research Institute, P.O. Box 10, Daejeon, Korea;(2) Department of Genetic Engineering, Sung Kyun Kwan University, 300 Chunchun-dong, 440-746 Suwon, Korea |
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| Abstract: | Summary Optimum specific growth rate for the production of recombinant bovine somatotropin (bST) was investigated in fed-batchE. coli fermentation with a controlled specific growth rate. Maximum specific bST concentration based on cell mass decreases linearly with the controlled specific growth rate. Productivity of bST is expressed by a quadratic equation as a function of the specific growth rate and has a maximum value at  =0.23 hr–1. |
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