Design, synthesis and biological evaluation of pyridine acyl sulfonamide derivatives as novel COX-2 inhibitors |
| |
Authors: | Lu Xiang Zhang Hui Li Xi Chen Guo Li Qing-Shan Luo Yin Ruan Ban-Feng Chen Xian-Wei Zhu Hai-Liang |
| |
Affiliation: | State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, PR China. |
| |
Abstract: | A series of pyridine acyl sulfonamide derivatives (1-24) have been designed and synthesized and their biological activities were also evaluated as potential cyclooxygenase-2 (COX-2) inhibitors. Among all the compounds, compound 23 displayed the most potent COX-2 inhibitory activity with an IC(50) of 0.8 μM. Antitumor and anti-inflammatory assays indicated that compound 23 owned high antiproliferative activity against B16-F10, HepG2 and MCF-7 cancer cell lines as well as COX-2-derived prostaglandin E(2) (PGE(2)) inhibitory activity of murine macrophage RAW 264.7 cell line with IC(50) values of 2.8, 1.2, 1.8 and 0.15 μM, respectively. Docking simulation was performed to position compound 23 into the COX-2 active site to determine the probable binding model. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|