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Synthesis and antimicrobial activity of brominated resorcinol dimers |
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| Authors: | Bouthenet Elise Oh Ki-Bong Park Seungil Nagi Navjeet K Lee Hyi-Seung Matthews Susan E |
| Affiliation: | School of Pharmacy, University of East Anglia, Norwich, United Kingdom. |
| Abstract: | Dibrominated resorcinol dimers were synthesized by reaction of 4-bromoresorcinol with aldehydes under reflux in ethanol in the presence of HCl. Subsequent dehalogenation yielded the corresponding monobrominated compounds and a fully dehalogenated dimer. Of the dimers, 6,6'-((4-hydroxyphenyl)methylene)bis(4-bromobenzene-1,3-diol) (4) displayed potent antibacterial activity and inhibitory activity against isocitrate lyase Candida albicans. |
| Keywords: | Bromophenol Red alga Antibacterial activity Antifungal activity Resorcinol |
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