Chloramphenicol and expression of multidrug efflux pump in Enterobacter aerogenes |
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Authors: | Ghisalberti Didier Masi Muriel Pagès Jean-Marie Chevalier Jacqueline |
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Institution: | Enveloppe Bactérienne, Perméabilité et Antibiotiques, EA2197, IFR48, Faculté de Médecine, Université de la Méditerranée, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France. |
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Abstract: | Chloramphenicol has been reported to act as an inducer of the multidrug resistance in Escherichia coli. A resistant variant able to grow on plates containing 64 microg/ml chloramphenicol was obtained from the Enterobacter aerogenes ATCC 13048-type strain. Chloramphenicol resistance was due to an active efflux of this antibiotic and it was associated with resistance to fluoroquinolones and tetracycline, but not to aminoglycoside or beta-lactam antibiotics. MDR in the chloramphenicol-resistant variant is linked to the overexpression of the major AcrAB-TolC efflux system. This overexpression seems unrelated to the global Mar and the local AcrR regulatory pathways. |
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Keywords: | Efflux pump Enterobacter aerogenes Chloramphenicol Efflux pump inhibitor Multidrug resistance |
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