Chromosome 13 restriction fragment length polymorphisms |
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| Authors: | T P Dryja J M Rapaport R Weichselbaum G A P Bruns |
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| Institution: | (1) Children's Hospital Medical Center, 243 Charles Street, 02114 Boston, MA, USA;(2) the Massachusetts Eye and Ear Infirmary, 243 Charles Street, 02114 Boston, MA, USA;(3) the Harvard School of Public Health, 243 Charles Street, 02114 Boston, MA, USA;(4) the Harvard Medical School, 243 Charles Street, 02114 Boston, MA, USA |
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| Abstract: | Summary The gene locus for hereditary retinoblastoma is on human chromosome 13, band q14. With this gene localization in mind, we cloned DNA fragments from this chromosome. Three of the fragments identify restriction fragment length polymorphisms. These three fragments are from the region 13q12–13q22, the chromosome region which contains the retinoblastoma locus. We expect that these restriction fragment length polymorphisms will be linked to the retinoblastoma locus, and that they will serve in certain retinoblastoma families as predictors of retinoblastoma gene carriers.They will also be useful in studies of other gene loci thought to be on chromosome 13.This research was supported by grants from the National Institutes of Health HD04807, CA29883, and EY04543, by a grant from Fight for Sight, Inc., New York City, and by the Anna Fuller Fund |
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