Effect of phloretin on chloride permeability: A structure-activity study |
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Authors: | JL Cousin R Motais |
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Institution: | Laboratoire de Physiologie Cellulaire, Faculté des Sciences, Parc Valrose 06034 Nice Cedex France |
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Abstract: | On the basis of data obtained with thin lipid membranes, phloretin's inhibition of chloride, urea and glucose transport in biological membranes has been suggested to be due to the effects of interfacial dipole fields on the translocator of these molecules (Andersen, O.S., Finkelstein, A., Katz,I. and Cass, A. (1976) J. Gen. Physiol. 67, 749–771).From the systematic analysis made in the present paper it effectively appears that the ability of phloretin analogs to inhibit chloride permeability in red-cell membrane depends on the capacity they have to alter the interfacial dipole potential: the magnitude of the potential change depending on the dipole moment of the molecule and its membrane concentration, it follows that the inhibitory capacity of a phloretin analog is a function of the dipole moment and the lipid solubility of the compound. |
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