Turbidity changes of lipid vesicles near the phase transition temperature as an indication of fusion |
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Authors: | O Avramovic-Zikic Konrad Colbow |
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Institution: | Department of Physics, Simon Fraser University, Burnaby, B.C. V5A 1S6 Canada |
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Abstract: | Sonicated liposomes of dipalmitoyl phosphatidylcholine show sharp turbidity changes on heating at two distinct temperatures. A decrease in turbidity at the lower temperature (approx. 37°C) is thought to be associated with the phase transition of small vesicles and a decrease at about 44°C with larger vesicles or multilayer. An increase of turbidity between 38 and 43°C is attributed to the fusion of small vesicles. The turbidity changes were studied under various modes of vesicle preparation to confirm the interpretation of the turbidity data. Alternate interpretations are discussed. |
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Keywords: | To whom reprint requests should be addressed |
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