Effect of cycloheximide on the induction of tryptophan oxygenase mRNA by hydrocortisone <span class="math"><math><mtext>in</mtext><mtext>vivo</mtext></math></span>期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Effect of cycloheximide on the induction of tryptophan oxygenase mRNA by hydrocortisone $in vivo$

Authors:	Linda DeLap Philip Feigelson

Institution:	1. Department of Biochemistry, College of Physicians and Surgeons, Columbia University, New York, N.Y. 10032 USA;2. The Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New York, N.Y. 10032 USA

Abstract:	Hydrocortisone increases rat liver tryptophan oxygenase mRNA activity as measured by a translational assay. Pretreatment of rats with cycloheximide thirty minutes before hydrocortisone administration largely prevents the hormonal induction of tryptophan oxygenase mRNA. Tryptophan oxygenase mRNA activity begins to increase after a lag of at least 30 to 60 minutes after hydrocortisone injection. These results suggest that the synthesis of intermediary protein(s) is required for the induction of tryptophan oxygenase mRNA by glucocorticoids.

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