Amiloride-induced stimulation of HCO3? reabsorption in turtle bladder |
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| Authors: | Gerhard Ehrenspeck John Durham William A Brodsky |
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| Institution: | Department of Physiology and Biophysics, Mount Sinai School of Medicine of the City University of New York, New York, N.Y. 10029 U.S.A. |
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| Abstract: | Amiloride in the mucosal fiuid (at concentrations of 5 · 10?6 M to 10?4 M) reversibly stimulates the HCO3?-dependent moiety of the short-circuiting current (Isc) in ouabain-treated turtle bladders bathed by Na-free Ringer solutions with or without Cl?.This effect is uniquely different from the known inhibitory effect of this agent on Na+ transport. Thus, any comprehensive hypothesis on the action of amiloride over a wide dosage-response fange should take into account its effect on HCO3? transport. |
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| Keywords: | To whom correspondence should be addressed |
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