The susceptibility of cholesterol-depleted erythrocytes to saponin and sapogenin hemolysis |
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| Authors: | Ruth Segal Ilana Milo-Goldzweig |
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| Institution: | Department of Pharmacognosy, School of Pharmacy, Hebrew University, Jerusalem Israel |
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| Abstract: | The assumption that complex formation between erythrocyte membrane cholesterol and saponins or sapogenins is the cause for their hemolytic activity, was tested by measuring the susceptibility of cholesterol-depleted erythrocytes towards these hemolysins. For some of the hemolysins cholesterol depletion caused inhibition of hemolysis, for others an augmentation. The results suggest that cholesterol does not serve as a specific binding site for these hemolysins. |
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