Resistance of planar bilayers of gangliosides |
| |
| Authors: | Susanna Yu. Tumanova Sergej A. Badjinyan Robert M. Nalbandyan |
| |
| Affiliation: | 1. Biological Department, Leningrad''s State University, Leningrad, USSR;2. Advanced Training Institute for Doctors, Yerevan, USSR;3. Institute of Biochemistry, Academy of Sciences, Armenian SSR, Yerevan, USSR |
| |
| Abstract: | The value of electrical resistance of planar bilayers (black membranes) of gangliosides was found to be sensitive to pH, the composition of ganglioside as well as the presence of phospholipids in bilayers. The pH-dependence of resistance of black mambranes prepared from porcine brain gangliosides was determined in the presence of K+, Na+, and Ca+2. In the absence of added phospholipids gangliosides obtained from brain of a patient with syndrom of Tay-Sachs disease are not capable to form stable black membranes, although in the presence of phospholipids the membranes are formed. The pH-dependences of resistance of black membranes obtained from mixture of phospholipids with gangliosides of porcine or human brain are compared. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
