Cyclic AMP transport in human erythrocyte ghosts |
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Authors: | G.D. Holman |
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Affiliation: | Department of Biochemistry, University of Bath, Bath BA2 7AY U.K. |
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Abstract: | 10?5 M cyclic AMP has high permeability in human erythrocyte ghosts (). Saturation of influx and efflux occurs. . . . at 30°C. Equilibrium exchange entry of cyclic AMP has similar kinetics to zero trans influx, though the system does show counterflow. Cythochalasin B is an apparent competitive inhibitor of cyclic AMP exit. ().Control experiments indicated that cyclic AMP remains intact during incubation with red blood cell ghosts and is contained within the intravesicular space during the transport experiments. |
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