| 自由基与视网膜色素上皮作用研究进展 |
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| 引用本文： | 王晓英,钱焕文. 自由基与视网膜色素上皮作用研究进展[J]. 激光生物学报, 2003, 12(6): 455-459 |
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| 作者姓名： | 王晓英 钱焕文 |
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| 作者单位： | 军事医学科学院放射医学研究所,中国北京,100850 |
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| 摘 要： | 自由基是不配对的电子结构，具有极其活泼的化学特性，体内过剩的自由基可与细胞和生物大分子相互作用，从而引起机体的过氧化损伤。视网膜色素上皮处在高氧和光照环境中，其发挥生理功能时容易受氧化损伤。本文介绍了自由基的概念、自由基致视网膜色素上皮氧化损伤机制、一氧化氮自由基与视网膜色素上皮和抗氧化剂等方面的内容。
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| 关 键 词： | 自由基 视网膜色素上皮 氧化损伤 线粒体 凋亡 |
| 文章编号： | 1007-7146(2003)06-0455-05 |
| 收稿时间： | 2003-04-16 |
| 修稿时间： | 2003-04-16 |
Development of Free Radical and Retinal Pigment Epithelial Action |
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| WANG Xiao-ying,QIAN Huan-wen. Development of Free Radical and Retinal Pigment Epithelial Action[J]. ACTA Laser Biology Sinica, 2003, 12(6): 455-459 |
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| Authors: | WANG Xiao-ying QIAN Huan-wen |
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| Abstract: | BFree radical is not pair-matching electronic structure with vivid chemical peculiarit, and superabundant free radical interacts on cell and biomolecule in vito induce superoxide injury of organism.The physiologic function of retinal pigment epithelial (RPE) cells is affected easily from oxidative damage in high density oxygen and photophas. In the paper,the concept of free radical, mechanism of oxidative damage of RPE ,nitric oxide and RPE were reviewed, and antioxidant were also introduced. |
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| Keywords: | free radical retinal pigment epithelial oxidative damage mitochondrion apoptosis |
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