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Stereospecific synthesis of a GS 4104 metabolite: determination of absolute stereochemistry and influenza neuraminidase inhibitory activity. |
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| Authors: | W Lew P A Escarpe D B Mendel D J Sweeny C U Kim |
| Institution: | Gilead Sciences Inc., Foster City, CA 94404, USA. |
| Abstract: | The total synthesis for the determination of the absolute stereochemistry of a GS 4104 metabolite 3 is described. In addition, the influenza neuraminidase inhibitory activity of 3 and related intermediates are reported. |
| Keywords: | |