Prediction of overall survival and response to immune checkpoint inhibitors: An immune-related signature for gastric cancer |
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| Authors: | Zheng Wang Xiang Li Ying Xu |
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| Institution: | aShanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, 200120 Shanghai, China;bShuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China;cLaboratory of TCM Four Processing, Shanghai University of Traditional Chinese Medicine, Shanghai, China;dHebei Agricultural University, Hebei, China |
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| Abstract: | Gastric cancer (GC) is common in East Asia and South and Central America. Most GC patients miss the opportunities for surgery. Despite their therapeutic potential, immune checkpoint inhibitors (ICIs) only work in part of patients with GC. Thus, this study was aimed at constructing a signature for diagnosis, prognosis, and prediction of response to ICIs. A multivariate analysis showed that the 8-immune-related-gene (IRG) signature was an independent prognostic factor of overall survival among GC patients. In the high-risk group of 8IRG signature risk score, the fractions of CD4 T cells, macrophage M2 and monocyte, which is associated with the progression of cancers, were higher. The low-risk group had a higher immunophenoscore, which meant a better response to ICIs. |
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