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Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years |
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| Authors: | Mendez Ivar Viñuela Angel Astradsson Arnar Mukhida Karim Hallett Penelope Robertson Harold Tierney Travis Holness Renn Dagher Alain Trojanowski John Q Isacson Ole |
| Affiliation: | Dalhousie University and Queen Elizabeth II Health Sciences Centre, Division of Neurosurgery and Department of Anatomy & Neurobiology, 1976 Summer Street, Halifax, Nova Scotia B3H 3A7, Canada. |
| Abstract: | Postmortem analysis of five subjects with Parkinson's disease 9-14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that included dopamine and serotonin neurons without pathology. These findings are important for the understanding of the etiopathogenesis of midbrain dopamine neuron degeneration and future use of cell replacement therapies. |
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