Direct resolution of optically active isomers on chiral packings containing ergoline skeleton. 6. Enantioseparation of profens |
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| Authors: | Olsovská J Flieger M Bachechi F Messina A Sinibaldi M |
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| Institution: | Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic. |
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| Abstract: | The enantioselective behaviour of some underivatized 2-arylpropionic acids (profens) and flobufen by HPLC using a terguride-based chiral stationary phase was tested. X-ray analysis of crystals of the chiral selector and its complexes with naproxen allowed a deeper insight into the enantiodiscriminative process. The column stability and reproducibility, and the potential of the packing for semipreparative scale separations were also determined. A method for determining flobufen enantiomers and metabolites in plasma samples is described. |
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