自由基与细胞凋亡

细胞凋亡是指细胞在生理和病理情况下的一种死亡模式，广泛涉及到肿瘤、衰老和退行性病变等一系列疾病．最近有实验表明自由基与细胞凋亡有密切的关系．凋亡细胞内活性氧自由基（ROS）生成增加，同时消除ROS的能力下降.大多数凋亡障碍的细胞表现出ROS分子大量减少，若调节细胞内ROS含量，死亡率能随之改变;离子辐射能通过经自由基引起细胞的凋亡，培养细胞在无血清或撤除生长因子后发生的死亡也大多与细胞内自由基代谢酶如过氧化氢酶等的活性变化有关.提示自由基是参与调节细胞凋亡的重要因素之一.

Free Radicals and Apoptosis

Apoptosis is a common mode of cell death occurring during development as well as in many pathological conditions, such as in tumor, aged and degenerative diseases. However, some experimental results recently demonstrate that free radicals involve in apoptosis. In apoptosis cells, the reactive oxygenspecies (ROS) production increases and the ability to metabolize ROS declines. The ROSin most disabled apoptosis cells is lower and the mortality of this kind of cells can be changed according to the amount of ROS in cells. irradiation can result in apoptosis damaged by hydroxyl free radical, the apoptosisphenomena in some cells come from withdrawing growth factor and medium may be caused by change of the free radical metabolic enzyme activity, such as peroxide hydrogen enzyme. The research summarized collectively suggest that free radical plays an important role in regulation of apoptosis.