| 核酸探针传感器的构建 |
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| 引用本文： | 陈誉华,宋今丹,李大为.核酸探针传感器的构建[J].生物化学与生物物理进展,1996,23(6):527-531. |
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| 作者姓名： | 陈誉华 宋今丹 李大为 |
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| 作者单位： | 中国医科大学细胞生物学卫生部重点实验室;中国医科大学细胞生物学卫生部重点实验室;沈阳东宇电子所 |
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| 基金项目： | 国家自然科学基金资助项目. |
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| 摘 要： | 依据石英振子的晶体谐振频率是其表面沉积物的函数，建立了简便、特异、敏感性达100pg，并能对受检样品相对定量的核酸杂交检测新方法，即压电晶体式核酸探针传感器，该方法的主要特点是以快速、敏感的频变信息作为核酸杂交的显示系统.
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| 关 键 词： | 核酸杂交 生物传感器 压电晶体 |
| 收稿时间： | 1995/12/4 0:00:00 |
| 修稿时间： | 7/8/1996 12:00:00 AM |
Study on Nucleic Acid Probe Sensor |
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| Chen Yuhu,Song Jindan and Li Dawei.Study on Nucleic Acid Probe Sensor[J].Progress In Biochemistry and Biophysics,1996,23(6):527-531. |
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| Authors: | Chen Yuhu Song Jindan and Li Dawei |
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| Institution: | Key Laboratory of ball Biology, China Medical University, Ministry of Public Health of China;Key Laboratory of ball Biology, China Medical University, Ministry of Public Health of China;Key Laboratory of ball Biology, China Medical University, Ministry of Public Health of China |
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| Abstract: | A new nucleic acid hybridizing assay, piezoelectric quartz-sensor which is capable of quantitative analysis has been established on the basis that the frequency of piezoelectric quartz vibration is the function to its surface sediment. The technique is simple, specific and sensitive up to 100 pg.It uses the rapid,sensitive frequency messages as the demonstration system of nucleic acid hybridization. |
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| Keywords: | nucleic acid hybridization biosensor piezoelectric quartz |
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