| 二酰基甘油调控细胞功能的机制 |
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| 引用本文： | 孙俊辉,朱培闳.二酰基甘油调控细胞功能的机制[J].生物化学与生物物理进展,1996,23(1):38-42. |
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| 作者姓名： | 孙俊辉 朱培闳 |
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| 作者单位： | 中国科学院上海生理研究所;中国科学院上海生理研究所 |
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| 摘 要： | 二酰基甘油(DG)是一些磷脂水解产生的一种有重要功能的第二信使，它主要通过激活细胞内的蛋白激酶C(PKC)进而磷酸化一系列底物蛋白，产生相应的细胞效应．在细胞整体水平，DG还是一种重要的脂类物质的代谢中介产物，通过若干代谢途径参与脂类和激素代谢循环，目前，有关DG调控细胞生理功能的研究，主要集中在细胞信号转导方面．
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| 关 键 词： | 二酰基甘油 肌醇磷脂 第二信使 细胞信号转导 蛋白激酶C |
| 收稿时间： | 1995/3/13 0:00:00 |
| 修稿时间： | 1995/5/11 0:00:00 |
The Mechanisms of the Modulation of Cellular Functions by Diacylglycerol |
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| Sun Junhui and Zhu Peihong.The Mechanisms of the Modulation of Cellular Functions by Diacylglycerol[J].Progress In Biochemistry and Biophysics,1996,23(1):38-42. |
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| Authors: | Sun Junhui and Zhu Peihong |
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| Institution: | Shanghai Institute of Physiology, Academia Sinica;Shanghai Institute of Physiology, Academia Sinica |
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| Abstract: | Diacylglycerol (DG), a product of the hydrolysis of some phospholipids, isthought to play important functions as a second messenger. DG can activate intracellular protein kinase C (PKC), which in turn phophorylates a variety of proteins and generates cellular effects. On the other hand,as an important intermediate of lipid metabolisms, DG in vivo is also involved in regulating lipid metabolisms and hormone cycles. The present researches on the mechanisms of the modulation of cellular functions by DG, are mostly concentrating on its effects on cellular signalling transduction. |
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| Keywords: | diacylglycerol (DG ) phophatidylinositol second messenger cellular signalling transduction protein kinase C (PKC) |
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