| 诱导免疫应答的一种新手段──基因免疫 |
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| 引用本文： | 雷章恒,潘星华,傅继梁. 诱导免疫应答的一种新手段──基因免疫[J]. 生物化学与生物物理进展, 1996, 23(4): 318-322 |
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| 作者姓名： | 雷章恒 潘星华 傅继梁 |
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| 作者单位： | 第二军医大学医学分子生物学开放实验室;第二军医大学医学分子生物学开放实验室;第二军医大学医学分子生物学开放实验室 |
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| 摘 要： | 近年来，一种诱导免疫应答的新手段─—基因免疫，正在引起人们越来越多的关注．所谓基因免疫，是将含有编码序列及必要表达调控元件的质粒DNA，直接导入动物组织，经诱导动物免疫系统对编码序列所表达的蛋白质发生免疫应答，达到免疫的目的．文章介绍了基因免疫的基本方法，综述了这一新兴领域中涉及传染病、肿瘤、移植等方面的研究成果及存在的问题，并展望了研究前景.
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| 关 键 词： | 基因免疫 质粒DNA 基因转移 |
| 收稿时间： | 1995-09-25 |
| 修稿时间： | 1995-12-18 |
A New Approach for Evoking an Immune Response: Gene Immunization |
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| Lei Zhangheng,Pan Xinghua and Fu Jiliang. A New Approach for Evoking an Immune Response: Gene Immunization[J]. Progress In Biochemistry and Biophysics, 1996, 23(4): 318-322 |
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| Authors: | Lei Zhangheng Pan Xinghua Fu Jiliang |
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| Affiliation: | Open Laboratory of Medical Molecular Biology, Second Military Medical University;Open Laboratory of Medical Molecular Biology, Second Military Medical University;Open Laboratory of Medical Molecular Biology, Second Military Medical University |
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| Abstract: | A new approach for evoking an immune response: gene immunization becomes more and more interesting for many researchers.Gene immunization is to introduce purified plasmid DNA which contains protein coding sequences and the necessary expressing regulatory elements into certain tissues of animals, in order to evoke the immune response to the proteins coded by the plasmid. The basic methods,achievements and problems of this new field are described here. |
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| Keywords: | gene immunization plasmic DNA gene transfer |
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