| 多肽核酸 |
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| 引用本文： | 张立刚,闵吉梅,张礼和. 多肽核酸[J]. 生物化学与生物物理进展, 1996, 23(3): 209-213 |
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| 作者姓名： | 张立刚 闵吉梅 张礼和 |
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| 作者单位： | 北京医科大学天然药物与仿生药物国家重点实验室 |
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| 摘 要： | 通过计算机模型设计出一种以肽骨架取代ＤＮＡ中脱氧核糖磷酸酯骨架的ＤＮＡ类似物．实验已证明其与互补寡核苷酸的结合具有高度的特异性．综述了其合成、杂交性及在分子生物学等方面的应用．
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| 关 键 词： | 多肽核酸 寡核苷酸 特异性 |
| 收稿时间： | 1995-06-29 |
| 修稿时间： | 1995-09-21 |
Peptide Nucleic Acid |
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| Zhang Ligang,Min Jimei and Zhang Lihe. Peptide Nucleic Acid[J]. Progress In Biochemistry and Biophysics, 1996, 23(3): 209-213 |
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| Authors: | Zhang Ligang Min Jimei Zhang Lihe |
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| Abstract: | A DNA analogue was designed in a computer model by replacing the deoxyribose phosphate backbone in DNA with a peptide backbone. Its binding to the complementary oligonucleotide was observed with great specificity. PNA's synthesis, hybridization and its application in moleuclar biology etc. were reviewed. |
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| Keywords: | peptide nucleic acid (PNA ) Oligonucleotides antisense hybridization specificity |
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