哺乳动物透明带糖蛋白及其生物活性

透明带在哺乳动物的受精过程中发挥着重要作用，透明带化学成分及其生物活性的研究对于了解精卵识别、顶体反应的诱导等过程的分子机理具有重要意义．近10年来的研究表明透明带主要由糖蛋白（ZPGPs）组成，是在细胞质内合成后转移至透明带的.大多数动物的ZPGPs为4～5种，不同种类动物的ZPGPs的氨基酸序列存在高度同源性.在受精过程中，ZPGPs具有精子受体和诱导顶体反应的双重作用，ZPGPs含有N－连接和O－连接寡聚糖，这些寡糖链是ZPGPs行使生物活性不可缺少的部分．

Glycoproteins in Zona Pellucida of Mammalian and Its Boiactivities

The mammalian zona pellucida plays a major role in the fertilization. The study of chemical substances in zona Pellucida and its bioactivities is of importance in studying the molecular mechanism of species-specific spermegg recognition and the induction of acrosome reaction. Studies in latest ten years show that zona pellucida mainly consists of glycoproteins which are synthesized inside oocyte and then tranferred to the outside of oocyte. Most animals have 4 or 5 kinds of ZPGPs, and of which proteins possess homologous. During the process of fertilization, ZPGPs are responsible for spermatozoa receptors and for the induction of acrosome reaction. ZPGPs contain N-linked and O-linked oligosaccharides, which are essential to the bioactivities of ZPGPs.