| 氧化与细胞凋亡 |
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| 引用本文： | 陆怡,潘华珍,许彩民.氧化与细胞凋亡[J].生物化学与生物物理进展,1996,23(2):118-121. |
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| 作者姓名： | 陆怡 潘华珍 许彩民 |
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| 作者单位： | 中国医学科学院基础医学研究所;中国医学科学院基础医学研究所;中国医学科学院基础医学研究所 |
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| 基金项目： | 国家自然科学基金资助项目. |
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| 摘 要： | 细胞凋亡(apoptosis)是细胞的主动死亡，它参与调节机体许多生理及病理过程．近年的研究表明细胞凋亡与氧化有密切关系．当细胞外诸如辐射、高氧、高温、感染、衰老等信息通过活性氧传入细胞，引起细胞脂质过氧化或与细胞凋亡有关的基因的表达，通过一系列生化反应，最终发生细胞凋亡．原癌基因bcl-2可能起着调节作用．
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| 关 键 词： | 细胞凋亡 氧化 膜脂质 |
| 收稿时间： | 1995/4/11 0:00:00 |
| 修稿时间： | 9/1/1995 12:00:00 AM |
Oxidative Stress induced Apoptosis |
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| Lu Yi,Pan Huazhen and Xu Caimin.Oxidative Stress induced Apoptosis[J].Progress In Biochemistry and Biophysics,1996,23(2):118-121. |
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| Authors: | Lu Yi Pan Huazhen and Xu Caimin |
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| Institution: | Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences;Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences;Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences |
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| Abstract: | Apoptosis, an active process of cellular self-destruction involved in a variety of physiological and pathological conditions, can be induced by either oxidants or stimulators of cellular oxidative stress. Mild damages such as ionizing and ultraviolet radiation, hyperoxia,hyperthermia, infection etc, will injure the cell via reactive oxygen species (ROS), which may either react with the polyunsaturated fatty acids,leading to the formation of oxidized lipids, or activate certain genes related to cell death. As a result, the cell commits suicide following a sequence of biochemical change. bcl-2, one of the proto-oncogenes, was found to play a role in the regulation of apoptosis. |
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| Keywords: | apoptosis oxidative stress membrane lipids |
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