吗啡和纳洛酮对酸化十二指肠引起狗胰液分泌的影响

本工作用制备 Thomas 胰瘘和胃痿的5条狗进行慢性实验。实验时用0.1N 盐酸灌入十二指肠以刺激胰液分泌,并分別注射吗啡或/和纳洛酮,观察它们对胰液分泌和对胰液中碳酸氢盐和蛋白质浓度的影响。另外我们还观察了吗啡和纳洛酮对6条狗离体胰主导管紧张性的影响。结果表明:(1)吗啡抑制了胰液分泌量,对胰液中碳酸氢盐和蛋白质浓度无影响,由于分泌量减少故两者的排出量显著减少(P<0.05),(2)纳洛酮本身对胰液分泌量和碳酸氢盐及蛋白质浓度均无影响;(3)纳洛酮可以加强吗啡抑制胰液分泌的作用(P<0.01);(4)吗啡能增加狗的离体胰主导管肌条的紧张性,纳洛酮不能阻断或翻转吗啡的这一效应,相反能加强其效应。本工作表明,吗啡抑制酸化十二指肠所引起的胰碳酸氢盐和蛋白质排出量,其机制可能是吗啡刺激胰导管收缩,而纳洛酮则加强吗啡的这种抑制效应。

Effects of morphine and naloxone on canine pancreatic secretion induced by acidified duodenum

Five mongrel dogs were prepared with chronic gastric and pancreatic fistulabefore experiment for insertion of cannula and collection of pancreatic juice.Panc-reatic secretion stimulated by infusion of 0.1 N HCl into the duodenum,can be pre-vented by i.v.injection of morphine and/or naloxone.The volume of pancreaticsecretion and the concentrations of bicarbonate and protein in the juice were assayed.The effects of morphine and/or naloxone on the tension of the muscular strip of mainpancreatic duct were also observed in vitro in six dogs.The results were as follows:(1)Morphine inhibited the volume of pancreatic secretion and decreased bicarbon-ate and protein outputs(P<0.05)but did not affect bicarbonate and protein con-centrations,(2)Naloxone per se had no effect on either pancreatic secretion orbiocarbonate and protein concentrations.(3)However,it would increase the in-hibitory effect of morphine on pancreatic secretion(P<0.01).(4)Morphine in-creased the tension of the muscular strip of the main pancreatic duct in vitro but thiswas not affected by naloxone.Taking all these observations together,the presentstudy suggests that the inhibitory effect of morphine on pancreatic bicarbonate andprotein outputs may be due to its contracting effect on pancreatic duct.