Colocalization of vasoactive substances in the endothelial cells of human umbilical vessels |
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| Authors: | W Q Cai K Dikranian P Bodin M Turmaine G Burnstock |
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| Institution: | (1) Department of Anatomy and Developmental Biology, University College London, Gower Street, WCIE 6BT London, UK;(2) Centre for Neuroscience, University College London, Gower Street, WCIE 6BT London, UK |
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| Abstract: | Human umbilical vessels are unique in lacking any innervation; thus endothelial cells may play the major role in local control and regulation of the blood flow. In the present study, we examined ultrathin sections of cultured human umbilical vein endothelial cells and tissue preparations of umbilical vein and artery, immunostained by the post-embedding colloidal gold double-labelling technique. We observed colocalization of atrial natriuretic peptide and neuropeptide Y, as well as colocalization of atrial natriuretic peptide and neuropeptide Y with other vasoactive substances, namely, vasoactive intestinal peptide, substance P, calcitonin gene-related peptide and arginine vasopressin. The functional significance of the colocalization of these vasoactive substances in the human umbilical vessel endothelial cells is discussed. |
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| Keywords: | Umbilical blood vessels Endothelial cells Vasoactive substances Colocalization Immunogold labelling Human |
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