Anticonvulsant activity of cyclopentano amino acids |
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Authors: | Robert Zand Ivan Izquierdo |
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Affiliation: | (1) Biophysics Research Division, Institute of Science and Technology and Department of Biological Chemistry, The University of Michigan, 48109 Ann Arbor, Michigan;(2) Department of Biological Chemistry, Institute Biociences Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil |
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Abstract: | The hypothesis that certain amino acid analogues possessing a five-membered ring structure or amino acid analogues that can be viewed as fragments derived from such a ring would have anticonvulsant activity was proposed and tested. The compounds 1-aminocyclopentane carboxylic acid, 1-amino-3-methylcyclopentane carboxylic acid, 3-aminotetrahydrothiophene carboxylic acid, and -aminoisobutyric acid were found to protect rats against seizures in the maximal electroshock test but offered no protection against metrazol-(pentylenetetrazol) induced seizures in mice. The structural feature of this class of anticonvulsants that allows for hydrophobic interactions at the receptor site is considered to be a major physical factor necessary in promoting the activity of this class of anticonvulsants. |
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